AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Recombinant Influenza Vectors Produce Antiviral Response.(Brief Article)
2001 OCT 10 - (NewsRx.com & NewsRx.net) --
by Michael Greer, senior medical writer - Hyperattenuated flu viruses transfected with HIV genetic material may be able to help prevent HIV infection, researchers in Austria report.
Boris Ferko and colleagues at Vienna's Institute of Applied Microbiology developed influenza virus-based vaccine vectors "containing an insertion of the 137 C-terminal amino acid residues of the human immunodeficiency virus type 1 (HIV-1) Nef protein into the influenza A virus nonstructural-protein (NS1) reading frame."
This vaccine triggered significant HIV specific immune responses in a murine model, according to their report in the October 2001 edition of the Journal of Virology.
Ferko and coworkers found cytotoxic T-lymphocyte activity specific to both influenza and HIV Nef in the spleens and respiratory tract lymph nodes of vaccinated mice. This response occurred in spite of the hyperattenuated phenotype of the recombinant virus vector, they noted.
Priming with a vector of the H1N1 influenza subtype followed by boosting with a H3N2 subtype vector augmented the antiviral response and extended it to murine urogenital tracts, study data showed. A double dose of H1N1 vectors followed by H3N2 subtype boosting resulted in the production of Nef-specific immunoglobulin G.
Despite the inability of recombinant ...
- HIV Nef inhibits T cell migration.
- Newspaper article from: Proteomics Weekly February 3, 2003 700+ words
...shed new light on the activity of the HIV Nef protein. This regulatory protein "has...to better characterize the effects of HIV Nef on T cell function by examining chemotaxis...signaling molecules." They found that "HIV Nef inhibited chemotaxis in response to SDF...
- HIV nef gene linked to vertical transmission.
- Newspaper article from: Genomics & Genetics Weekly September 5, 2003 700+ words
...NewsRx.com & NewsRx.net) -- The HIV nef gene appears to play a key role in mother-to-child transmission of the virus. HIV nef "is conserved among members of human...and conservation of functionality" of HIV nef "during maternal-fetal transmission...
- HIV Nef protein protects infected cells from apoptosis.
- Newspaper article from: AIDS Weekly March 11, 2002 700+ words
...Michael Greer, senior medical writer - The HIV Nef protein helps to prolong the lives of...The researchers found that part of the HIV Nef protein contains the binding domain for...reported in this study include: * The HIV Nef protein helps prevent apoptosis in HIV...
- HIV Nef does not affect the efficiency of viral cell fusion.
- Newspaper article from: Biotech Week November 12, 2003 700+ words
2003 NOV 12 - (NewsRx.com & NewsRx.net) -- The HIV Nef protein does not affect the efficiency of viral cell fusion. HIV Nef "stimulates viral infectivity by an unknown mechanism," scientists in Tennessee explained. "Recent studies...
- HIV Nef protein enhances Tat-induced gene expression.
- Newspaper article from: Virus Weekly September 23, 2003 700+ words
2003 SEP 23 - (NewsRx.com & NewsRx.net) -- The HIV Nef protein enhances Tat-induced viral gene expression. HIV Nef "is now regarded as a regulatory protein responsible not only for establishment of infection ana increased pathogenesis...
- HIV Nef transports cholesterol to lipid rafts and virions.
- Newspaper article from: Biotech Week September 17, 2003 700+ words
2003 SEP 17 - (NewsRx.com & NewsRx.net) -- The HIV Nef protein transports cholesterol to lipid rafts and virions...colleagues at the University of California-San Francisco found that HIV Nef "not only increased the biosynthesis of lipid rafts and viral...
- Experiments on Different Immunization Routes with Two HIV-Nef Encoding...
- Newspaper article from: Vaccine Weekly August 9, 1999 700+ words
...Therapy "Experiments on Different Immunization Routes with Two HIV-Nef Encoding Plasmids." A. Collings, M. Strengell, M. Tahtinen...and cell mediated immune responses. Our aim was to use our HIV-Nef expressing plasmids to inoculate mice in different ways and...
- HIV Nef plays key role in virus-induced podocyte dedifferentiation.
- Newspaper article from: Proteomics Weekly November 17, 2003 700+ words
2003 NOV 17 - (NewsRx.com & NewsRx.net) -- The HIV Nef protein plays a key role in virus-induced podocyte dedifferentiation. According to published research from the United States...