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Favorable Genetic Factors Same For Progression, Vaccine Efficacy.(Brief Article)
2001 OCT 3 - (NewsRx.com & NewsRx.net) --
by Michael Greer, senior medical writer - Gene polymorphisms linked to favorable prognoses after HIV infection are also associated with positive responses to HIV vaccines, researchers say.
"Carriers of certain human leukocyte antigen [HLA] class I alleles show favorable prognosis of human immunodeficiency virus type 1 (HIV-1) infection, presumably due to effective CD8(+) cytotoxic T-lymphocyte responses, but close relationships between class I variants mediating such responses to natural and to vaccine HIV-1 antigen have not been established," explained Richard A. Kaslow and colleagues at the University of Alabama at Birmingham, the Duke University Medical Center, and pharmaceutical company Aventis Pasteur in France.
Kaslow and coworkers found that people with HLA class I genetic factors associated with slower disease progression were much more likely to show HIV specific immune responses after inoculation with recombinant canarypox-based vaccines.
Carriers of the B(*)27 allele were more than 10 times as likely as noncarriers to display cytotoxic T-cell responses to the HIV Gag protein 2 weeks after their second vaccination, study data showed. More than 60% of B(*)27 carriers showed such a response, and a third had demonstrated multiple reactions two weeks after their third or fourth dose.
Vaccine recipients with the B(*)57 allele had similarly positive reactions, Kaslow and coauthors reported. Two weeks after the last dose, almost 40% had achieved two or more T-cell responses to both HIV Gag and Env, a significant improvement over patients without this polymorphism.
Surprisingly, patients with HLA class I factors linked to poor HIV prognoses had vaccine responses similar to ...
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Source: HighBeam Research, Favorable Genetic Factors Same For Progression, Vaccine...