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Some Vaccines May Boost Immune System.(Brief Article)
2001 OCT 3 - (NewsRx.com & NewsRx.net) --
Vaccines intended to protect people from getting AIDS may also work as a treatment for those already infected, boosting their immune system so they can temporarily stop taking AIDS drugs.
So-called therapeutic vaccines, which harness the body's own immune system to control HIV, have long been a goal of research. However, data released at an AIDS vaccine conference in Philadelphia September 7, 2001, are the first to hint this may be an effective strategy when combined with standard AIDS drugs.
The idea is to give people a break from their AIDS medicines that could last for weeks, months or even years. Experts caution that much more experimentation is needed to know whether vaccines could be used safely and effectively this way.
Nevertheless, dozens of possible new AIDS vaccines are in development, and while most have not yet reached human testing, drug companies are designing many of them for use both to prevent AIDS and to treat it.
Furthest along in this kind of dual testing is Aventis Pasteur's ALVAC-HIV, which has been given to more than 1,900 people worldwide and will enter large-scale testing to prevent AIDS next summer. The vaccine consists of a harmless canary pox virus that is genetically engineered to carry several genes that make HIV proteins. The company is sponsoring 14 studies of the vaccine as a treatment for infected people in the United States and Europe.
Normally, when people stop taking their AIDS drugs, the virus can reproduce again rampantly, producing billions of new copies. By exposing the immune system in advance to HIV proteins, experts hope it will mount a vigorous defense against the re-emerging virus, knocking it down to acceptably low levels.
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Source: HighBeam Research, Some Vaccines May Boost Immune System.(Brief Article)