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High-Dose, Short-Interval Hep B Vaccine Works In Liver Disease Patients.(Brief Article)
2001 OCT 3 - (NewsRx.com & NewsRx.net) --
by Sonia Nichols, senior medical writer - A higher dose, shorter interval hepatitis B vaccine regimen is effective for protecting patients with chronic liver disease who have yet to be affected by cirrhosis.
Based on a study of 224 individuals with varied degrees of liver disease, medical investigators at Loyola University in Maywood, Illinois report that when cirrhosis is not present, chronic liver disease patients can be protected against hepatitis B virus (HBV) infection with altered hepatitis B vaccine regimens.
During the vaccine study, Nicola De Maria and colleagues gave chronic active hepatitis patients, cirrhosis patients, and healthy controls three high-dose injections (40 (micro)g) of HBV vaccine over three consecutive months. Normally, the doses would have been lower and spread out over a longer period of time.
According to De Maria and coworkers, 62% of the chronic liver disease patients developed an immune response against HBV after receiving the accelerated vaccine regimen. Almost all of the controls (92%) were protected after high-dose, short-interval vaccination, while only 42% of the patients with cirrhosis achieved an immune response to HBV ("Increased effective immunogenicity to high-dose and short-interval hepatitis B virus vaccination in ...
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Source: HighBeam Research, High-Dose, Short-Interval Hep B Vaccine Works In Liver Disease...