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Plant Virus-Based Vaccines Can Be Effective.(Brief Article)
2001 OCT 3 - (NewsRx.com & NewsRx.net) --
by Michael Greer, senior medical writer - Plant viruses can be used as the basis for potent vaccines for HIV and possibly other infections, according to researchers in Italy.
Eugenio Benvenuto and colleagues at the Institute for New Energy and Environmental Technology (ENEA) and the Istituto Superiore di Sanita in Rome reported the results of their study on the "high-yield expression of a neutralizing epitope from human immunodeficiency virus type 1 (HIV-1) on the surface of a plant virus and its immunogenicity" in the September issue of the Journal of Virology.
Plant virus-based vaccines induced strong antiviral responses in a murine model, according to their report.
The researchers studied the possibility of using recombinant potato virus X (PVX) to provoke HIV specific antibody responses. They engineered the PVX coat to express a highly conserved epitope from the HIV protein gp41, and administered the resulting chimeric virus particles (CVPs) to mice.
The animals studied demonstrated a strong response to this vaccine, pumping out HIV specific immunoglobulin G (IgG) and IgA antibodies, Benvenuto and coworkers reported. Moreover, severely immune-deficient mice with human T cells responded to gp41 challenge with a human antibody ...
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