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Rhesus Monkeys Protected Against AIDS By Live Vaccine.(Brief Article)
2001 OCT 3 - (NewsRx.com & NewsRx.net) --
More than 22 million people worldwide have died of AIDS. With millions of new infections each year, a safe and effective AIDS vaccine is imperative.
In the past year or so, groups at Harvard Medical School, Beth Israel Deaconess Hospital and Emory University have reported some success in controlling the proliferation of an HIV-like virus in monkeys by vaccinating with DNA fragments similar to those found in that virus.
However, a glance at the history of disease control shows that the most effective vaccines, e.g., the polio vaccine, have been based on live viruses. These can be absorbed through the mouth or nose with no need for an injection, making them easier and cheaper to administer, especially in developing countries, which are suffering most from the AIDS epidemic.
The main problem with using this approach for AIDS has been the risk of disease associated with a live HIV vaccine.
But in 1995, John Rose and colleagues at Yale University's School of Medicine developed a method of engineering the vesicular stomatitis virus (VSV), an RNA virus, to express foreign genes.
"Having developed the VSV recombinants, you can put the HIV genes, ...
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Source: HighBeam Research, Rhesus Monkeys Protected Against AIDS By Live Vaccine.(Brief Article)