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Peptide Immunizations Lower Diabetic Incidence In Animal Model.(Brief Article)
2001 OCT 3 - (NewsRx.com & NewsRx.net) --
by Sonia Nichols, senior medical writer - Stanford University researchers in California have developed a DNA vaccine that prevents animals from developing insulin-dependent diabetes mellitus (IDDM).
The vaccine, comprising insulin peptide particles, exploits immune response mechanisms before autoimmune factors can affect insulin production in nonobese diabetic mice (NOD), I. Urbanek-Ruiz and colleagues reported in Clinical Immunology.
"IDDM is an autoimmune disease characterized by T-cell mediated destruction of the insulin-secreting beta cells in the pancreas," Urbanek-Ruiz and coworkers explained.
Using genetic material encoding for peptide residues 9 through 23 from the beta chain of insulin, the group developed a DNA vaccine that proved effective when inoculated into NOD mice, normally used for modeling IDDM.
"Animals injected intramuscularly with a bacterial plasmid encoding the insulin B chain peptide show significantly lower disease incidence and delayed onset of disease when compared to controls," investigators stated.
Further vaccine development might prove fruitful for preventing or limiting T-cell mediated ...
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