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AP Vaccine Safe And Immunogenic In Cincinnati Outbreak.(acellular pertussis vaccine)
2001 SEP 19 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Hospital workers vaccinated against pertussis during a Cincinnati outbreak apparently were well-protected, proving that the vaccine can be immunogenic even in an adult population.
C.D. Christie and colleagues working at Cincinnati's Children's Hospital Medical Center randomized workers to receive either acellular pertussis (AP, n=102) vaccine or licensed meningococcal vaccine (MN, n=97) for their study appearing in Clinical Infectious Diseases.
The AP vaccine contained 25 (micro)g of pertussis toxoid (PT) and 3 (micro)g of filamentous hemagglutinin (FHA). One month after AP vaccination, the geometric mean level of immunoglobulin G (IgG) anti-PT was 33.1 (micro)g/mL, reported Christie and associates. Eighty-five percent of patients had twofold increase in anti-PT antibodies and 73% had fourfold increase. The respective values for anti-FHA IgG were 34.7 (micro)g/mL, 92%, and 63%.
Local and systemic reactions were similar for both AP and MN groups ("A trial of acellular pertussis vaccine in hospital workers during the Cincinnati pertussis epidemic of 1993," Clin Infect Dis, October ...
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Source: HighBeam Research, AP Vaccine Safe And Immunogenic In Cincinnati Outbreak.(acellular...