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West African Neonates Would Benefit From Earlier Vaccination.
2001 SEP 19 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Children who are born prematurely or who have low birth weight may be good candidates for early vaccination, researchers in West Africa have found.
A study of women in a Gambian hospital labor ward shows that prematurity and low birth weight are associated with lower transfer of antibodies from mother to child, rendering these neonates more vulnerable to viral and bacterial infection, said J.B. Okoko and colleagues.
Their physician-blinded, cross-sectional study of 213 mother-baby pairs evaluated maternal and cord serum samples for specific immunoglobulin G antibody titers for measles virus (MeV), herpes simplex virus type 1 (HSV1), respiratory syncytial virus (RSV), varicella-zoster virus (VZV), tetanus toxoid (TT) and diphtheria toxoid (DT) antigens using enzyme linked immunosorbent assay.
Premature and low-birth-weight infants were significantly more likely to have reduced placental antibody transfer than babies with adequate birth weight, reported Okoko and coworkers ("The influence of prematurity and low birthweight on transplacental antibody transfer in a rural West African population," Tropical Medicine & International Health, 2001;6(7):529-534).
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Source: HighBeam Research, West African Neonates Would Benefit From Earlier Vaccination.