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DNA PSA Vaccine Safe And Immunogenic In Macaques.(prostate-specific antigen)
2001 SEP 19 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A DNA vaccine expressing human prostate-specific antigen (PSA) shows promise in rhesus macaques, researchers in the United States have found.
J.J. Kim and colleagues at the University of Pennsylvania previously reported on the use of a DNA vaccine that encodes for human PSA to elicit host immune responses against cells producing PSA. Here, they examined immune responses and safety profiles in macaques immunized with DNA-based PSA vaccine.
"DNA immunization strategy delivers DNA constructs encoding for a specific immunogen into the host, who becomes the in vivo protein source for the production of antigen," explained Kim and coworkers. "This antigen then is the focus of the resulting immune response."
They found that the vaccinated animals showed both PSA-specific humoral response and positive PSA-specific lymphoproliferative (LPA) response and that their stimulated T cells produced higher levels of Th1 type cytokine IFN-gamma than the control vector-immunized animals.
DNA immunization did not cause any adverse effects in these animals, ...
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Source: HighBeam Research, DNA PSA Vaccine Safe And Immunogenic In Macaques.(prostate-specific...