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New Vaccine Offers Good Protection In Animal Models.(prevention of bubonic and pneumonic plague)
2001 SEP 19 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A new subunit vaccine against bubonic and pneumonic plague appears safe and effective in animal models, researchers in England report.
If endorsed for human use, the vaccine, based on the F1- and V- antigens of Yersinia pestis, could help overcome some of the problems associated with current plague vaccines
"Plague still occurs throughout the world today, though for reasons that are not fully understood pandemics of disease do not develop from these outbreaks," wrote R.W. Titball and colleagues in Vaccine.
Although bubonic plague usually can be treated with antibiotics, they pointed out, pneumonic plague is harder to treat and is often fatal. The killed whole-cell vaccine that has been used in the past was recently shown to have poor efficacy in animals, but the more effective live attenuated vaccine retains some of its virulence and thus is considered inappropriate for human use in most countries, said Titball and coworkers.
A new subunit vaccine based on the F1- and V- antigens is highly effective against ...
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Source: HighBeam Research, New Vaccine Offers Good Protection In Animal Models.(prevention of...