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Rabies-Based Vector Triggers Anti-Gag Response.(shows promise as HIV vaccine)
2001 SEP 19 - (NewsRx.com & NewsRx.net) --
by Michael Greer, senior medical writer - Rabies virus-based vectors that express the Gag protein have shown promise as an HIV vaccine candidate, researchers in the United States report.
"Recent research suggests that the HIV-1 Gag protein is [an] important target for cell-mediated host immune defense," according to Matthias J. Schnell and colleagues at Thomas Jefferson University in Philadelphia and George Washington University in Washington, DC.
Schnell and coworkers demonstrated that rabies virus vectors can efficiently express Gag and that such constructs can trigger antiviral immune responses in a murine model.
HeLa cells infected with Gag-expressing rabies virus expressed p55, the precursor protein for the HIV core, according to the report. Moreover, infected cells released both virus-like particles similar to HIV and rabies virus particles with the same bullet shape as the HIV core.
The research team tested the efficacy of their vaccine candidate in vivo using BALB/c mice. After a single inoculation with recombinant rabies virus, the mice ...
- Region of rabies virus glycoprotein plays important pathogenic role.
- Newspaper article from: Vaccine Weekly May 5, 2004 700+ words
...Nishigahara strain of rabies virus is required to lethality...acids 164 to 303 of the rabies virus glycoprotein plays...major subject areas of Rabies Virus, Zoonosis, Proteomics...article was prepared by Vaccine Weekly editors from staff...
- Modified rabies virus vectors safe, effective.
- Newspaper article from: Vaccine Weekly January 8, 2003 700+ words
...medical writer - Novel rabies virus (RV)-based vaccines...Second-generation rabies virus-based vaccine vectors...Second generation rabies virus (RV) HIV vaccine...article was prepared by Vaccine Weekly editors from staff...
- Findings from Y.Z. Zhang and co-authors provide new insights into rabies virus.
- Newspaper article from: Virus Weekly August 12, 2008 700+ words
...healthy animals are potential carriers of rabies virus in China, 153 domestic dogs were collected...for 6 months. Initially, findings of rabies virus antigen in the saliva of 15 dogs by...the ELISA test alone, detection of rabies virus antigen in saliva of some animals was...
- Reports from G. Sato and co-researchers add new data to research in rabies...
- Newspaper article from: Virus Weekly March 10, 2009 700+ words
...position 333 on the glycoprotein of the rabies virus is considered necessary for virulence...only been found in fixed strains of rabies virus. In this study, the authors found...333Q substitutions at this position in rabies virus street strains isolated from non-hematophagous...
- New rabies virus study findings have been reported by researchers at Trent...
- Newspaper article from: Virus Weekly October 14, 2008 700+ words
...genome of a mid-Atlantic raccoon strain rabies virus (RRV) isolated in Canada was sequenced...is the second North American wildlife rabies virus isolate to be fully characterized...Peterborough, Canada report (see also Rabies Virus). "The nucleotide sequence identity...
- Rabies virus in raccoons, Ohio, 2004.(DISPATCHES)
- Magazine article from: Emerging Infectious Diseases Henderson, J. Caroline Biek, Roman Hanlon, Cathleen A. O'Dee, Scott Real, Leslie A. April 1, 2008 700+ words
In 2004, the raccoon rabies virus variant emerged in Ohio beyond...containment and elimination of the rabies virus variants associated with this species...goal of eliminating particular rabies virus variants from their respective...
- New rabies virus research from M.A. Neubaum and colleagues discussed.
- Newspaper article from: Virus Weekly August 19, 2008 700+ words
...The literature supports that unique rabies virus (RABV) variants are often compartmentalized...the United States report (see also Rabies Virus). "RABV associated with this species...analysis of correspondence between unique rabies virus variants and divergent big brown bat...
- From rabies virus to anti-HIV vaccine.(Brief Article)
- Magazine article from: Science News N.S. April 8, 2000 700+ words
...University in Philadelphia reconstructed a rabies virus to the point that it no longer caused...mice. Five others received weakened rabies virus without the gp 160-production capability...to slay the cells they invade. This rabies virus doesn't kill the cells it takes over...
- Researchers discover an improved method for recovering rabies virus from...
- Newspaper article from: Virus Weekly March 18, 2003 700+ words
...discovered an improved method for recovering rabies virus from cloned cDNA. "A new system for recovery of rabies virus from cDNA plasmid, the transcription...RNA polymerase produced a recombinant rabies virus in several cell lines," wrote K...
- Detection of rabies virus by PCR difficult due to virus heterogeneity.
- Newspaper article from: Biotech Week March 17, 2004 700+ words
...amp; NewsRx.net) -- Detection of rabies virus RNA by polymerase chain reaction is...based method for the detection of rabies virus (RV) RNA in tissue samples. We show...Evaluation of a TaqMan PCR assay to detect rabies virus RNA: Influence of sequence variation...
Source: HighBeam Research, Rabies-Based Vector Triggers Anti-Gag Response.(shows promise as HIV...