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Preterm Infants At Greater Risk Of Vaccine-Related Adverse Events.
2001 SEP 19 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Premature infants are at greater risk than those carried to term for adverse reactions to diphtheria and tetanus toxoids and pertussis/Haemophilus influenzae type B conjugate (DPT/Hib) vaccines, according to a new report in Acta Paediatrica.
Waiting until these children are at least 70 days old to vaccinate them, however, can avert major adverse events, found S. Sen and colleagues at the Royal Gwent Hospital, Newport, UK. They retrospectively studied the medical histories of 45 preterm babies vaccinated in the neonatal intensive care unit between January 1993 and December 1998. They recorded birth weight, gestational age, duration of ventilation, oxygen dependency, timing of vaccination, weight, corrected gestation at vaccination, and apparent adverse effects from vaccination.
Nine of the babies (20%) had major adverse events such as apnea, bradycardia, or desaturations and eight (17.8%) had minor events, including increased oxygen requirements, temperature instability, poor handling, and feed intolerance, for a total of 37.8% affected, reported Sen and coworkers.
Babies with major events were significantly younger, had a lower postmenstrual age, and weighed less at the time of vaccination than babies without major events, the authors noted.
Infants who were younger than 70 days at vaccination had a significantly higher risk of adverse events: of 27 babies vaccinated when they were 70 days or younger, nine (33.3%) developed major events, compared with none of ...
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