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Micro- and Macrometastatic Growth Patterns Differ In Human Tumors.(Brief Article)
2001 SEP 6 - (NewsRx Network) -- by Sonia Nichols, senior medical writer -- A new study has revealed metastatic growth patterns emerge differently in patients with breast cancer.
Those differences show up in comparisons between lymph node evaluations of micrometastases or macrometastases, according to Nancy Klauber-DeMore and coworkers at Memorial Sloan-Kettering Cancer Center in New York City.
"Clinically undetectable micrometastases may account for disease recurrence in breast cancer patients after variable disease-free intervals," Klaber-DeMore and coworkers said in a report on the new research.
To understand how growth patterns evolve in patients with micrometastatic breast cancers as compared with macrometastatic malignancies, Klaber-DeMore and team evaluated several growth regulation processes, including proliferation, apoptosis, and angiogenesis, in the lymph nodes of equal numbers of women with one or the other form of metastases.
Both median proliferation rates and microvessel densities were significantly higher for macrometastases than micrometastases, according to the authors. However, apoptosis as determined by an apoptotic ...
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Source: HighBeam Research, Micro- and Macrometastatic Growth Patterns Differ In Human...