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Phase I Study Of Antibody Therapy Initiated.(Brief Article)
2001 SEP 12 - (NewsRx.com & NewsRx.net) --
MedImmune, Inc. (MEDI) announced that it has begun dosing rheumatoid arthritis patients with Vitaxin(TM) in a Phase I clinical trial.
Vitaxin is an antibody that has the potential to inhibit the progression of a variety of diseases, including rheumatoid arthritis, psoriasis, psoriatic arthritis, and certain forms of cancer and eye disease. Vitaxin appears to work by binding to a specific integrin (alpha-V-beta-3) expressed on a number of cells, such as newly forming blood vessels (angiogenesis), bone resorbing osteoclasts, and activated macrophages. Both angiogenesis and osteoclast-mediated osteolysis (bone destruction) are key elements involved in the development of rheumatoid arthritis.
"We are very pleased to begin our clinical development for Vitaxin in rheumatoid arthritis," said Dr. Ronald Wilder, MedImmune. "We believe that Vitaxin may have the ability to impede the advancement of this disease by exerting both anti-angiogenic and anti-osteolytic effects through its blocking of alpha-V-beta-3. The data we collect from this trial will complement the research effort we previously initiated with Vitaxin in the cancer ...
- MedImmune Initiates Clinical Study With Vitaxin(TM) In Rheumatoid Arthritis...
- Press release article from: PR Newswire August 6, 2001 700+ words
...begun dosing rheumatoid arthritis patients with Vitaxin(TM) in a Phase...development for Vitaxin in rheumatoid arthritis," said Dr...B) doses of Vitaxin in patients with active rheumatoid arthritis who are currently...
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- Press release article from: PR Newswire September 9, 2003 700+ words
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- Applied Molecular Evolution Announces the Achievement of Two Clinical...
- Press release article from: PR Newswire September 10, 2003 700+ words
...of Phase II clinical trials for Vitaxin(R) in both cancer and rheumatoid arthritis. Vitaxin is a monoclonal antibody that MedImmune...as in the damage done to bone in rheumatoid arthritis. Vitaxin is a Registered Trademark of MedImmune...
- MEDIMMUNE DROPS VITAXIN IN RA, PSORIASIS; OTHER WORK CONTINUES By Kim Coghill...
- Magazine article from: BIOWORLD Today August 31, 2004 700+ words
...Phase II trials of Vitaxin in rheumatoid arthritis and psoriasis prompted...oncology program for Vitaxin is ongoing, Jamie...inflammatory trials. Vitaxin is the subject of...trials in 2005. The rheumatoid arthritis (RA) trial included...
- Vitaxin trials discontinued in rheumatoid arthritis and psoriasis.
- Newspaper article from: Drug Week October 1, 2004 700+ words
...terminate phase II testing of Vitaxin in patients with rheumatoid arthritis (RA) and psoriasis based...MedImmune's oncology program for Vitaxin continues to advance with...melanoma and prostate cancer. Vitaxin targets the alpha-v beta...
- MedImmune Discontinues Rheumatoid Arthritis and Psoriasis Trials for Vitaxin(R).
- Press release article from: PR Newswire August 30, 2004 700+ words
...terminate Phase 2 testing of Vitaxin(R) in patients with rheumatoid arthritis (RA) and psoriasis based...s oncology program for Vitaxin continues to advance with...and prostate cancer. About Vitaxin Vitaxin targets the alpha...
- MedImmune to Study Therapeutic Benefit of Vitaxin(R) To Treat Prostate Cancer...
- Press release article from: PR Newswire December 17, 2003 700+ words
...evaluate the activity of Vitaxin on psoriasis. In September...two Phase 2 trials with Vitaxin, involving patients with melanoma and rheumatoid arthritis (RA). "We believe...preclinical models, that Vitaxin's novel mechanism of...
- Two clinical milestones achieved for Vitaxin.
- Newspaper article from: Immunotherapy Weekly October 8, 2003 700+ words
...clinical trials for Vitaxin in both cancer and rheumatoid arthritis. Vitaxin is a monoclonal antibody...structural joint damage in rheumatoid arthritis. Financial terms of...were not disclosed. "Vitaxin is the most clinically...
