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Diphtheria Antibodies Linked To Pneumococcal Vaccine Response.(Brief Article)
2001 SEP 12 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Low levels of diphtheria toxin antibodies in the elderly may be responsible for their weaker immune response to pneumococcal vaccine, say researchers working in the United States.
"In older adults, using conjugation to protein carriers to improve the immune response to pneumococcal polysaccharide vaccine has thus far proved disappointing," noted M.A. Shelly and colleagues. "Low immunity to the carrier protein in the elderly may explain the failure of conjugated vaccines to elicit a T-cell-dependent response."
The researchers immunized 49 older adults (ages 60-78) and 50 younger adults (ages 18-45) with either 23-valent pneumococcal polysaccharide (PS) vaccine or 5-valent CRM197-conjugated pneumococcal oligosaccharide. They measured antibodies to pneumococcal serotypes 14 and 6B and diphtheria toxin by enzyme-linked immunosorbent assay before and after vaccination.
Older adults showed lower baseline diphtheria toxin antibody levels than younger adults (0.31 vs. 0.88 IU/ml) and that, in turn, was associated with lower antibody levels to PS type 6B after vaccination (3.5 vs. 9.9 (micro)/ml), reported Shelly and ...
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Source: HighBeam Research, Diphtheria Antibodies Linked To Pneumococcal Vaccine Response.(Brief...