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Breakthrough Mouse Model Has Both Amyloid Plaques And Neurofibrillary Tangles.(Brief Article)
2001 SEP 12 - (NewsRx.com & NewsRx.net) --
Researchers at Mayo Clinic in Jacksonville, Florida, have successfully bred mice exhibiting amyloid plaques and neurofibrillary tangles, the two key pathologic hallmarks of Alzheimer disease (AD).
Until now, an animal model that exhibited both of these brain lesions did not exist.
The breakthrough is expected to provide investigators a better animal model in which to test therapies aimed at preventing or halting progression of the degenerative brain disease affecting approximately four million Americans. The Mayo Clinic team of Michael Hutton, PhD; Dennis Dickson, MD; Jada Lewis, PhD; Shu-Hui Yen, PhD; and Eileen McGowan, PhD, published its work in the August 24, 2001, issue of Science.
Many researchers studying potential causes of AD suspect that when amyloid beta protein deposits in the brain to form plaques, the phenomenon sets off a cascade of pathology that leads to AD. Somewhere in the disease process neurofibrillary tangles, caused by abnormal tau protein, develop in the brain, and brain cells die as well. No one has proven whether the plaques lead to tangles or vice versa.
The Mayo group bred a mouse they genetically engineered to develop neurofibrillary tangles with a mouse similarly engineered to develop amyloid plaques. Hutton believes the resulting double transgenic mouse strengthens the amyloid cascade hypothesis.
"The evidence we've got is consistent with that," Hutton says. "What we saw in the crossbred mice were not only plaques and tangles, but the tangle pathology was enhanced in ...
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