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Immunostimulatory DNA Sequences Stimulate Immune Responses.(Brief Article)
2001 SEP 12 - (NewsRx.com & NewsRx.net) --
Dynavax's proprietary immunostimulatory DNA sequences (ISS) have been shown effective in producing potent immune responses in mice when linked to envelope protein gp120 antigen.
In the study, the researchers used mice to compare the immune response of vaccines consisting of the HIV gp120 antigen administered alone, in combination with ISS and in an ISS-antigen linked format. Both ISS containing vaccines elicited potent antigen-specific immune responses characterized by the production of antibodies, Th1 cytokines, CCR5-specific beta-chemokines and killer T-cell activity.
These responses were achieved systemically as well as at mucosal sites and are thought to be necessary for an effective HIV vaccine. In general, the antigen alone and other controls either induced no response or only a weak antibody response.
For almost all immune responses, the linked vaccine showed statistically significant improvement over the coadministered vaccine. Furthermore, the linked vaccine was able to induce a strong CD8 T cell response that was shown to be independent of CD4 T cell help. This is of particular importance in the context of a ...
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Source: HighBeam Research, Immunostimulatory DNA Sequences Stimulate Immune Responses.(Brief...