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Simplified Test Offers Accurate Evaluation Of Insulin Sensitivity In Women With PCOS.(polycystic ovary syndrome)
2001 AUG 23 - (NewsRx Network) -- by N.R. Saltmarsh, staff medical writer - A simplified version of the continuous infusion of glucose with model assessment (CIGMA) test can be used to evaluate insulin sensitivity in women with polycystic ovary syndrome (PCOS), say researchers working in Norway.
Normally, measurements of insulin and glucose concentrations are taken at 50, 55, and 60 minutes in the CIGMA test, but Y. Wang and colleagues at the National Hospital of Norway, Oslo, have found that taking these values at 60 minutes only is just as reliable for determining insulin sensitivity.
They tested 97 women with PCOS using CIGMA values obtained at 50, 55, and 60 minutes of glucose infusion and interpreted these values using a mathematical model of glucose and insulin homeostasis, to produce an insulin resistance index (IR1). Using the same mathematical model and the 60-minute value only, they calculated a second index (1R2).
Also obtained for comparison were fasting insulin, fasting C-peptide, fasting glucose, fasting insulin:glucose ratio, and fasting C-peptide:glucose ratio ("Simplification of continuous infusion of glucose with model assessment in the evaluation of insulin resistance in women with PCOS," Gynecological Endocrinology, 2001;15(3):192-197).
Wang and associates found significant correlations ...
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Source: HighBeam Research, Simplified Test Offers Accurate Evaluation Of Insulin Sensitivity In...