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Irregular Growth Factor Levels Mark Heightened Risk During Pregnancy.(for developing pre-eclampsia)
2001 AUG 23 - (NewsRx Network) -- by Sonia Nichols, senior medical writer - Monitoring plasma levels of an important human growth factor might clue doctors in to a pregnant patient's risk for developing pre-eclampsia.
Based on a study of 60 pregnant women with mild or severe pre-eclampsia, doctors say plasma levels of a growth factor responsible for new blood vessel growth and permeability called VEGF (vascular endothelial growth factor) tend to rise in pre-eclamptic women to such high levels that those values can discriminate mild disease from severe disease.
The rise in VEGF levels in women with pre-eclampsia appears to be caused by a complex cascade of biochemical events, according to E.M. Elsalahy and other doctors in Cairo, Egypt at Aim Shams University who studied the women. A decrease in plasma nitrate levels was associated with increased hypertension and constricted blood vessels, associating with a rise in VEGF levels. These changes were accompanied by increases in lipid peroxides, which were not counteracted because plasma levels of vitamin E, an important antioxidant, had fallen in the pre-eclamptic women ("New scope in angiogenesis: Role of vascular endothelial growth factor (VEGF), NO, lipid peroxidation, and vitamin E in the pathophysiology of pre-eclampsia among Egyptian females," Clinical ...
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Source: HighBeam Research, Irregular Growth Factor Levels Mark Heightened Risk During...