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Vaccine Achieves Protection When Delivered With MF59 Adjuvant.(Brief Article)
2001 SEP 5 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A nonpathogenic variant of influenza A/Hong Kong/97 (H5N1) appears to be a good vaccine candidate against the virus when administered with MF59 adjuvant, researchers working in England report.
K.G. Nicholson and colleagues at Leicester Royal Infirmary tested influenza A/Duck/Singapore/97 (H5N3) as a vaccine candidate for influenza A (H5N1) following its emergence in 1997.
They administered 7.5, 15, or 30 (micro)g hemagglutinin surface-antigen influenza A H5N3 vaccine plus MF59 to 32 healthy volunteers, and without adjuvant to 33 subjects, in two doses given three weeks apart.
The A/Duck/Singapore vaccines were safe and well-tolerated although antibody response was poor when adjuvant was not used, reported Nicholson and team. The geometric mean titers of antibody, and seroconversion rates, were significantly higher after MF59 adjuvanted vaccine, and in fact, two 7.5 (micro)g doses of MF59 adjuvanted vaccine gave the highest seroconversion rates ("Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 ...
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