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Virus-Like Particles Induce Antibody, Cytokine Responses In Chimps.(Brief Article)
2001 SEP 5 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Chimpanzees vaccinated with virus-like particles (VLPs) of human papillomavirus (HPV) are able to mount antibody and cytokine responses to various HPV types, a finding that holds promise for human vaccine development.
"We evaluated antibody, cytokine (interferon-gamma, interleukin-5, tumor necrosis factor-alpha), and cytotoxic T lymphocyte (CTL) responses in chimpanzees immunized with monovalent or quadrivalent (HPV-6, -11, -16, -18) L1 VLP vaccines administered intramuscularly on aluminum hydroxyphosphate (alum) at weeks 0, 8 and 24," reported T.J. Palker and colleagues working in the United States.
The researchers employed radioimmunoassay (RIA) four weeks after the second and third immunizations to measure maximum serum antibody titers to type-specific, neutralizing epitopes on HPV-11 or -16 L1 VLPs. They found that, depending on the VLP type used for immunization, HPV type-specific cytokine responses were most frequently seen four weeks after the second or third immunizations and between weeks 44-52.
HPV-16 L1-specific CTL activity was observed only from weeks 16-24 in 3 of 22 (13.6%) chimpanzees immunized with HPV-16 L1 VLPs, they noted ("Antibody, ...
- Virus-Like Particles Induce Antibody, Cytokine Responses In Chimps.
- Newspaper article from: Biotech Week September 5, 2001 700+ words
...mount antibody and cytokine responses to various HPV types, a finding...for immunization, HPV type-specific cytokine responses were most frequently...antibodies and Th1 and Th2 cytokine responses to several HPV types; however...
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- Local immune, systemic cytokine responses are related to postherpetic neuralgia.
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- Juvenile rhesus monkeys have lower type 2 cytokine responses than adults.
- Newspaper article from: Medical Letter on the CDC & FDA May 11, 2003 700+ words
...suggest that juvenile rhesus monkeys have reduced type 2 cytokine responses after primary schistosome infections and perhaps are more...Infectious Diseases (Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni...
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- Magazine article from: Townsend Letter: The Examiner of Alternative Medicine Yanick, Paul, Jr. August 1, 2006 700+ words
...with botanicals or mycomedicinals, although helpful, may weaken the thymus and disrupt the TH-1 and TH-2 cytokine responses. Blood levels of thymic hormones are typically low in the elderly, infection-prone individuals, and in patients...
- Immunology (Malaria) "Cytokine Responses During Acute Simian Malaria Infection...
- Newspaper article from: Immunotherapy Weekly December 7, 1998 700+ words
A.D. Praba, F. Cogswell, S. Montenegro-James and M.A. James. Tulane Regional Primate Research Ctr., Covington, LA; Molecular Immunogenetics Laboratory, Ochsner Medical Foundation, New Orleans, LA; Tulane University Medical Ctr., New Orleans, LA. According to an abstract submitted by the authors to
- Correlation of in vitro cytokine responses with the chemical composition of...
- Magazine article from: Environmental Health Perspectives Veranth, John M. Moss, Tyler A. Chow, Judith C. Labban, Raed Nichols, William K. Walton, John C. Watson, John G. Yost, Garold S. March 1, 2006 700+ words
We treated human lung epithelial cells, type BEAS-2B, with 10-80 [micro]g/[cm.sup.2] of dust from soils and road surfaces in the western United States that contained particulate matter (PM) < 2.5 pm aerodynamic diameter. Cell viability and cytokine secretion responses were measured at 24 hr.
