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Gelatin Sensitivity Explains Some Delayed Reactions to JE Vaccine.(Brief Article)
2001 SEP 5 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Children who are allergic to gelatin-based products may have delayed allergic reaction to Japanese encephalitis (JE) vaccine.
Although gelatin sensitivity was previously thought to account only for immediate-type reactions to JE vaccine (defined as within one hour), less was known about the source of non-immediate reactions, which include cutaneous signs emerging several hours or more after vaccination, noted M. Sakaguchi and colleagues at the National Institute for Infectious Diseases, Tokyo.
The researchers evaluated serum samples from 28 JE-vaccinated children who showed delayed allergic reactions such as urticaria, angioedema, and rash, and from 10 children who showed immediate allergic reactions.
All 10 children who showed immediate-type reactions had anti-gelatin IgE and IgG, and of 28 children with nonimmediate-type reactions, one had anti-gelatin IgE and nine (32%) had anti-gelatin IgG, reported Sakaguchi and coworkers. The child who had anti-gelatin IgE showed urticaria two hours after JE vaccination, they added ("Specific IgE and IgG to gelatin in children with systemic cutaneous reactions to Japanese encephalitis vaccines," Allergy, ...
- JE vaccine import raises controversy.
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- News wire article from: PTI - The Press Trust of India Ltd. November 14, 2005 700+ words
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- Acambis inks agreement with Bharat Biotech for JE vaccine.
- News wire article from: PTI - The Press Trust of India Ltd. November 9, 2005 700+ words
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- Milestone for Acambis on JE vaccine research.(Food and Drug Administration...
- Newspaper article from: Pharma Marketletter November 21, 2005 700+ words
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- Intercell starts Ph III trial of JE vaccine.(Japanese encephalitis)
- Newspaper article from: Pharma Marketletter September 26, 2005 700+ words
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- Acambis' JE vaccine enters pivotal Ph III trials.
- Newspaper article from: Pharma Marketletter November 28, 2005 700+ words
UK vaccine specialist Acambis says that the development of ChimeriVax-JE, its vaccine for Japanese encephalitis, has entered Phase III with two trials together enrolling 2,800 healthy volunteers. These are: a 2,000 patient safety and an 800-strong efficacy study, testing the non-inferiority of
- Sera against ChimeriVax-JE vaccine protects against encephalitis virus.
- Newspaper article from: Immunotherapy Weekly November 24, 2004 700+ words
2004 NOV 24 - (NewsRx.com & NewsRx.net) -- Passive transfer of sera raised against ChimeriVax-JE experimental vaccine protected against Japanese encephalitis virus strains. "The ability of antisera raised against a candidate Japanese encephalitis virus (JEV) vaccine, ChimeriVax-JE, and the
