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VEGF-C Aligns With Invasion In Gynecological Cancer Cell Lines.(vascular endothelial growth factor C)
2001 AUG 9 - (NewsRx Network) -- by Sonia Nichols, senior medical writer - Of several types of angiogenic factors, VEGF-C (vascular endothelial growth factor C) most closely associates with invasion and metastases in in vitro analyses of gynecological cancers.
Scientists in Japan have tested several forms of VEGF along with basic fibroblast growth factor (bFGF) and matrix metalloproteinase (MMP)-2 for their effects on invasive activity in 16 different gynecological cancer cell lines. Their results showed that VEGF-C was the most active angiogenic factor in terms of in vitro invasion, which may hold true for in vivo gynecological cancers as well.
"Expression of VEGF-A mRNA was detected in all 16 cell lines, whereas the relative expression levels of other VEGF family members and bFGF differed markedly among the cell lines," said Masatsugu Ueda and coworkers at Osaka Medical College in Japan.
VEGF-C was the only one of the major angiogenic factors to show a statistically significant association between cellular expression and cell migration and invasion ("Vascular endothelial growth factor C gene ...
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