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Interleukin-6 In Microenvironment May Support Tumor Growth.(cervical cancer research)
2001 AUG 9 - (NewsRx Network) -- by Sonia Nichols, senior medical writer - A new study suggests increased levels of interleukin (IL)-6 may promote cervical cancer growth and tumor vascularity in females.
Researchers in Taiwan at National Taiwan University performed the new study, evaluating levels of IL-6, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) in the cytosol of tumor specimens acquired from women with stage IB-IIA cervical cancers. Investigators detected such high levels of the cytokine in the tumors of cervical cancer patients that they predicted controlling its expression could stem or even prevent tumor growth.
"Consistently higher expression of IL-6 and VEGF was evident in cancerous tissues than in adjacent noncancer tissues in early-stage cervical cancer patients (P[less than]O.01)," Lin-Hung Wei and associates commented in the report.
When IL-6 was added to a cervical cancer cell line (C33A), VEGF expression increased in relation to both time and dose. Likewise, VEGF expression fell when investigators inhibited IL-6 production in another cervical cancer cell line (SiHa) using antibodies to IL-6 and its receptor.
While looking for factors associated with elevated IL-6 expression in the malignancies of early-stage cancer patients, Wei and coworkers found that several stood out. Those factors included being older than 45 years, having tumors greater than 2 cm, being ...
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- Interleukin-6 In Microenvironment May Support Tumor Growth.(in cervical cancer)
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- Phase II Clinical Trial Of MVA-HPV-IL2 Initiated.(Transgene begins trials for...
- Newspaper article from: Immunotherapy Weekly December 19, 2001 700+ words
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