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Researchers Test Post-Trauma Vaccination In Animals.(Brief Article)
2001 AUG 22 - (NewsRx.com & NewsRx.net) --
Researchers in Israel are exploring a remarkable strategy by which animals may be vaccinated against the effects of spinal cord injury.
They discuss their work in the August 2001 issue of the Journal of Clinical Investigation.
While vaccination could hardly be expected to prevent a physical trauma, Ehud Hauben and colleagues at the Weizmann Institute of Science note that much of the tissue destruction and nerve death that leads to paralysis following mild trauma to the spine occurs a week or more after injury and is mediated by immune cells.
Building on their previous observation that exogenous T cells specific for central nervous system self antigens can block these harmful responses, these researchers have tested whether vaccination with CNS proteins or peptides can activate endogenous T cells to provide mice a similar protective autoimmunity ("Posttraumatic T-cell-based therapeutic vaccination suppresses autoimmune responses and prevents complete paralysis," J Clin ...
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