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Vaccine Confers Protection On Tribal Children, Despite Malarial Endemicity.
2001 AUG 15 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Children from two tribes in the Amazon region benefited from a measles vaccination program, despite living in a remote area that is endemic for malaria, say researchers working in Brazil.
R. Spindel and colleagues evaluated measles vaccination efficacy in children from two Indian tribes - Caiabi and Metuktire - in the Parque Indigena do Xingu (PIX). Vaccinees included 37 Caiabi and 28 Metuktire children, 20-75 months old who received the first dose on average at 11.5 months and the second at 20 months.
Immunofluorescence assay was used to measure immunoglobulin (Ig) G antibodies against measles virus and Plasmodium falciparum.
Measles vaccine coverage was 60% at 12 months of age and 92% at 18 months, and postvaccine serum conversion was 95% in Caiabi children and 89% in Metuktire, reported Spindel and coworkers.
Seventy-three per cent of Caiabi children and all of the Metuktire children were Plasmodium antibody positive, showing they had been exposed to malarial infection. Despite these differences, Spindel and team found the immune response to measles vaccine to be satisfactory in both groups, and noted that it was consistent with that in nonmalarial areas of the Americas ("Measles ...
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Source: HighBeam Research, Vaccine Confers Protection On Tribal Children, Despite Malarial...