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Proposed Change In Postexposure Treatment Probably Unnecessary.(Brief Article)
2001 AUG 15 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Intradermal preexposure vaccination against rabies is adequate to mount an early immune response following postexposure vaccination, researchers in Australia have found.
"Post-exposure treatment (PET) of travelers who may have had a potential rabies exposure is simpler, safer, and cheaper if the traveler is pre-immunized," explained A.W. Gherardin and colleagues in Melbourne. "Some authorities, however, are now advocating that travelers vaccinated by the intradermal (ID) route should be treated as if they are not immunized."
There were concerns that travelers who received preexposure rabies vaccination ID would have a delayed response to postexposure boosters, said Gherardin and team.
To test the validity of this theory, the researchers administered human diploid cell rabies vaccine (HDCV) in a simulated postexposure situation to 29 subjects who had received three ID preimmunizations 12-24 months earlier and compared rabies antibody levels before and five days after the booster.
Nine of the 29 subjects (31%) had inadequate antibody levels prior to the simulated postexposure booster. Five days after the postexposure booster, 27 of 29 (93%) had adequate antibody levels, and the other two travelers were subsequently shown to have adequate virus-neutralizing antibody levels when tested four and six weeks later, respectively, the authors said ("Early rabies antibody response to intramuscular booster in previously intradermally immunized travelers using human ...
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Source: HighBeam Research, Proposed Change In Postexposure Treatment Probably Unnecessary.(Brief...