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Human Vaccine Development Closer To Reality.(Helicobactor pylori vaccine)
2001 AUG 15 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Adjuvants approved for use in humans show promise as vaccine components with Helicobacter pylori antigen in mice, bringing a human vaccine one step closer to fruition, according to a new report in the Journal of Infectious Diseases.
J.M. Gottwein and colleagues at Case Western Reserve University, Cleveland, Ohio, immunized mice systemically with H. pylori antigen and aluminum hydroxide (AlOH), which stimulated interleukin (IL) 5-secreting, antigen-specific T cells, or with antigen and complete Freund's adjuvant, which induced interferon-gamma-secreting, antigen-specific T cells.
Both immune responses conferred protection after challenge with either H. pylori or H. felis, which was confirmed by the complete absence of any bacteria, reported Gottwein and coworkers.
Protection was antibody independent, as demonstrated with antibody-deficient mice (immunoglobulin-gene knockout mice), and CD4(+) spleen T cells from immunized mice were sufficient to transfer protective immunity to otherwise immunodeficient rag1(-/-) recipients, added Gottwein and associates ("Protective ...
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