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Skin Patch Superior To Oral Estrogen On Sympathetic Nerve Activity.
2001 JUL 12 - (NewsRx Network) -- Researchers at the University of Texas (UT) Southwestern Medical Center in Dallas report that administering replacement estrogen via a skin patch is superior to oral estrogen replacement therapy in lowering blood pressure and sympathetic nerve activity - the neural control of blood pressure - in postmenopausal women.
The study was published in the June 19, 2001, issue of Circulation. It is the first study to compare the effectiveness of oral and transdermal replacement therapies on sympathetic nerve activity in humans. These findings suggest that the route by which estrogen is administered is the key to optimizing the beneficial effects of estrogen replacement therapy on blood pressure, said Dr. Wanpen Vongpatanasin, assistant professor of internal medicine, UT, and lead author of the study.
"Prevalence of hypertension is very low in young pre-menopausal women but increases markedly after menopause, suggesting a protective role of estrogen on blood pressure. Knowledge from this study may lead to an effective therapy to treat or prevent hypertension after menopause," she said.
Vongpatanasin and her colleagues reported that transdermal estrogen, or the estrogen patch, decreased nerve activity in postmenopausal women with normal blood pressure by 30%. The researchers also reported a small, but statistically significant, decrease in blood pressure in patients taking transdermal estrogen. Both nerve activity and blood pressure were unaffected in patients taking oral estrogen.
"This is an initial step that leads us to think that all estrogen preparations are not the same," Vongpatanasin said. "This may be one of the reasons why large clinical trials failed to show a benefit of estrogen replacement therapy on blood pressure or any cardiovascular outcomes. It could very well be because only oral estrogen, the most popular preparation in the United States, has been used rather than transdermal estrogen."
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