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Ocular Destruction Follows Plasminogen Activator Response.(Brief Article)
2001 AUG 8 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - An overexpression of plasminogen activators and inhibitors may be the mechanism behind blindness following corneal infection with Pseudomonas aeruginosa, say researchers working in the United States.
R.S. Berk and colleagues, Wayne State University, Detroit, Michigan, sought to clarify the role of plasminogen activators in the inflammatory response to P. aeruginosa by challenging immunized and unimmunized mice with the pathogen intracorneally.
They found that naive mice showed a temporally enhanced expression of tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), its receptor (uPAR), and plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2) over the course of several days, but immunized mice showed low levels of these factors for a short duration.
These responses eventually led to corneal destruction in the naive mice and healing in the immunized mice, reported Berk and coworkers ("Plasminogen activators and inhibitors in the corneas of mice infected with Pseudomonas aeruginosa," Investigative Ophthalmology and Visual Science, 2001;42(7):1561-1567).
Expression of these factors at the mRNA and protein levels may have been due to enzymes and inhibitors ...
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