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Mutant Ras Peptides Induce Hypersensitivity Reactions.(Brief Article)
2001 AUG 8 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Vaccinating melanoma patients with mutant ras stimulates strong, delayed-type hypersensitivity reactions and occasionally an in vitro T-helper response, according to a report in Experimental Dermatology.
"The proteins of the ras-family of proto-oncogenes, functioning as relay switches for signaling pathways between cell surface and nucleus, are involved in cell proliferation, differentiation, apoptosis, and transformation," explained R.E. Hunger and colleagues at the University of Bern, Switzerland. "If over-expressed or mutated they can induce and/or maintain a transformed state of a cell."
Melanoma development on sun-exposed sites, for example, appears to be associated with codon 61 mutations of N-ras, noted Hunger and associates.
To evaluate the immune response toward mutated N-ras proteins in melanoma patients, the researchers vaccinated 10 patients six times using N-ras peptides with four codon 61 mutations and GM-CSF as adjuvant. Eight patients had strong delayed-type hypersensitivity reactions and two had an in vitro response to the vaccine, they reported ("Successful induction of immune responses against mutant ras in melanoma patients using intradermal injection of peptides and GM-CSF as adjuvant," ...
- ONCOGENE SCIENCE, INC. RECEIVES BROAD U.S. PATENT COVERING ALL ANTIBODIES...
- Press release article from: PR Newswire April 5, 1994 700+ words
...monoclonal antibodies specific for oncogenic mutant ras proteins. These antibodies are useful in detecting mutant ras proteins which have been shown to be...well as the only ELISA test to detect mutant ras proteins. "Strengthening our intellectual...
- Dominant-Negative Mutant Ras Expression In Vivo Inhibits Tumor Growth.
- Newspaper article from: Gene Therapy Weekly June 7, 2001 700+ words
2001 JUN 7 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, PhD, staff medical writer - Transgenic studies in Japan hold promise for the treatment of badder cancer. Researchers there found the expression of a negative H-ras mutant in human bladder cancer cells implanted in mice decreased
- Dominant-Negative Mutant Ras Expression In Vivo Inhibits Tumor Growth.(Brief...
- Newspaper article from: Cancer Weekly June 5, 2001 700+ words
2001 JUN 5 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, PhD, staff medical writer - Transgenic studies in Japan hold promise for the treatment of badder cancer. Researchers there found the expression of a negative H-ras mutant in human bladder cancer cells implanted in mice decreased
- Ras Vaccine Prolongs Survival in Patients With Advanced Disease.(Brief Article)
- Newspaper article from: Vaccine Weekly June 6, 2001 700+ words
...that a vaccine incorporating mutant ras peptides could be effective. They vaccinated...intradermal injection with synthetic mutant ras peptides in granulocyte-macrophage...cancer patients with synthetic mutant ras peptides plus granulocyte-macrophage...
- Selected ongoing clinical trials *. (Featured CME Topic: Thyroid...
- Magazine article from: Southern Medical Journal May 1, 2002 700+ words
...323-3778. VACCINE THERAPY WITH TUMOR SPECIFIC MUTATED RAS PEPTIDES AND IL-2 OR GM-CSF FOR ADULT PATIENTS WITH SOLID TUMORS...histologically diagnosed solid tumors potentially expressing mutant Ras, including colon, lung, pancreas, thyroid, endometrial...
- ACE inhibitors and ARBs: antihypertensive medications in CKD.(Clinical Consult)
- Magazine article from: Nephrology Nursing Journal Szromba, Charlotte May 1, 2005 700+ words
...clinical trials have indicated that angiotensin II can be generated by enzymes other than ACE and that angiotensin II and other RAS peptides bind to receptors with differing functional consequences. The RAS system is more complex than previously thought. So it...
- Tripep's RAS Technology and the German Biotech Company Cosmix' mRNA Display...
- Newspaper article from: Biotech Week September 9, 2009 700+ words
...rapidly are identified. Opsonic will use Cosmix technology to identify target-binding peptides and these are then used in RAS peptides aimed for therapeutic use (see also Tripep). Cosmix AG has developed a mRNA Display Library by which ligand binding peptide...
- Prophylactic Immunization May Actually Stimulate Tumor Growth.(cancer vaccines)
- Newspaper article from: Immunotherapy Weekly August 9, 2000 700+ words
...The mice carry in the germline a mutant ras oncogene that has an arginine at codon...F1 mice were immunized with Arg(12) mutant ras peptide in complete Freund's adjuvant...vitro when stimulated with the Arg(12) mutant ras peptide. In addition, by day 14, these...
