AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
LYMErix(R) Found Immunogenic, Well Tolerated In Children.(Brief Article)
2001 AUG 8 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A recombinant vaccine comprising the outer surface protein A (OspA) of Borrelia burgdorferi (LYMErix(R)) generates antibody levels in children three times those of vaccinated adults, researchers in the United States have found.
The vaccine, which is generally safe and well-tolerated in this age group, is likely to protect against Lyme disease (LD), said V.K. Sikand and colleagues at Tufts University, Boston.
They randomized children four to 18 years old living in Lyme endemic areas to receive either 30 (micro)g of LD vaccine (n=3,063) or placebo (n=1,024) at baseline, one, and 12 months. Immunogenicity results were compared with those of adults receiving the same vaccine in a previous study.
Vaccine recipients had a higher incidence of injection site and systemic reactions compared with placebo recipients, but the majority of events lasted only two to three days and were not severe, reported Sikand and coworkers.
Among the subset of 301 LYMErix vaccinated children for whom immunogenicity was evaluated, the total immunoglobulin G (IgG) anti-OspA geometric mean titer (GMT) at month 13 was statistically higher than the GMT in the adult cohort at month 13 (27,485 enzyme-linked immunosorbent assay units [EL.U]/mL vs. 8,216 EL.U/mL), noted Sikand et al.
All of the pediatric vaccine recipients attained antibody concentrations of at least the proposed seroprotective level of 1400 EL.U/mL. By comparison, 90% of adults attained levels >=1400 EL.U/mL ("Safety and immunogenicity of a recombinant Borrelia ...
- Studies from G. Stubs and colleagues reveal new findings on lyme disease.
- Newspaper article from: Vaccine Weekly July 15, 2009 700+ words
...colleagues (see also Lyme Disease). The researchers...of Borrelia Causing Lyme Disease and Frequently Induce...Infectious Disease, Lyme Disease, Vaccination. This article was prepared by Vaccine Weekly editors from staff...
- Vaccine containing outer-surface protein A protects against Lyme disease.
- Newspaper article from: Vaccine Weekly April 9, 2003 700+ words
...using the search term "Lyme disease vaccine" yielded 6...received a booster of a Lyme disease vaccine containing...resulting from the Lyme disease vaccine were common...article was prepared by Vaccine Weekly editors from staff...
- CDC announces new awards for Lyme disease research.
- Newspaper article from: Vaccine Weekly April 28, 2004 700+ words
...reducing the incidence of Lyme disease in endemic areas. 10) Prevention of Lyme disease in Connecticut. Matthew...reduce the risk of Lyme disease in the United States...article was prepared by Vaccine Weekly editors from staff...
- Lyme disease: this tick-borne illness can fool even experts. Don't let it ruin...
- Magazine article from: Current Health 2, a Weekly Reader publication Monroe, Judy March 1, 2004 700+ words
...to doctors for more tests. The diagnosis: Lyme disease. For some people, Lyme disease is a minor illness. They run a fever and...quickly and are cured. For other people, Lyme disease is a serious illness. They can develop major...
- Lyme Disease
- Encyclopedia entry from: The Gale Encyclopedia of Science January 1, 2008 700+ words
Lyme Disease Lyme disease is an infection transmitted by the bite of ticks carrying the spiral...it is recognized early and treated properly with antibiotics. Lyme disease is a vector-borne disease, which means it is delivered from...
- Lyme disease puzzling Texans.(Knight Ridder Newspapers)
- Newspaper article from: Knight Ridder/Tribune News Service Mitchell, Mitch September 1, 2002 700+ words
...FORT WORTH, Texas _ Many Texans diagnosed with Lyme disease tell the same story. They say they never felt...and multiple sclerosis before learning she had Lyme disease. Whether Lyme disease is prevalent in Texas has caused a dispute in...
- Chronic Lyme disease research center established at Columbia...
- Magazine article from: Townsend Letter: The Examiner of Alternative Medicine Cohen, Marcus A. April 1, 2007 700+ words
...we are opening the Columbia University Lyme Disease Research Center, a state-of-the...spiral-shaped bacteria) that cause Lyme disease. The New Jersey-based national Lyme Disease Association and the Connecticut-based...
- Lyme disease prevention and treatment.(THE EFFECTIVE PHYSICIAN)
- Magazine article from: Internal Medicine News Golden, William E. Hopkins, Robert H. December 1, 2006 700+ words
...identification and management of Lyme disease and other zoonoses associated with...organisms responsible for causing Lyme disease, human granulocytic anaplasmosis (HGA), and babesiosis. Lyme disease is caused by infection with the...
Source: HighBeam Research, LYMErix(R) Found Immunogenic, Well Tolerated In Children.(Brief...