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Aged Mice Only Partly Protected By Adjuvant-Combined Vaccine.(Brief Article)
2001 AUG 8 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A study appearing in Vaccine has found that influenza vaccines confer only partial protection on some strains of older mice, but completely protect younger mice, suggesting a weakening of immune responses with age.
H. Asanuma and associates in Japan compared antibody responses after intranasal vaccination of two-month-old and 18-month-old BALB/c, C3H, and C57BL/6 (B6) mice that were immunized with 2.5 (micro)g protein of A/PR/8/34 (PR8) (H1N1) virus vaccine containing a cholera toxin adjuvant.
Both young and aged BALB/c mice exhibited high levels of PR8-specific antibody-forming cell (AFC) responses in nasal-associated lymphoid tissue (NALT) seven days after immunization. By four weeks post-vaccine, younger mice had slightly higher nasal wash immunoglobulin A (IgA) and serum IgG antibody (Ab) responses to the PR8 hemagglutinin (HA), reported Asanuma and coworkers.
IgG1 and IgG2a levels were significantly lower in the aged mice, they added, and the young mice were completely protected against later challenge infection, while the aged mice were only partially protected.
In the C3H mice, NALT-AFC and IgA and IgG Ab responses were higher in the young mice than in the aged mice although only IgG2a was significantly ...
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