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Lipopeptides Can Induce HIV Specific Immune Responses.(Brief Article)

Vaccine Weekly

| August 08, 2001 | COPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 AUG 8 - (NewsRx.com & NewsRx.net) --

by Michael Greer, senior medical writer - Lipopeptides from HIV proteins may provide the basis for an HIV vaccine, researchers in France report.

Gilles Pialoux and colleagues at Rothschild Hospital and other institutions in Paris and Lille, conducted a study to determine the "efficacy of a mixture of six NEF (N1, N2, N3), GAG (G1, G2) and ENV (E) lipopeptides in the induction of B- and T-cell anti-HIV responses." The results of this study were published in the July 2001 edition of the journal AIDS.

Most of the HIV negative study participants displayed specific immune responses to one or more of tested peptides, Pialoux and coworkers said.

Almost 90% (25 of 28) of the volunteers showed HIV specific antibody responses after three peptide injections. T lymphocytes proliferated in response to at least one peptide in 19 of 24 evaluable volunteers (79%), and 14 of those participants achieved proliferative T-cell response to two or more peptides, study data showed.

More than half (13 of 24) of the volunteers displayed "clear and reproducible" HIV specific CD8 cell responses, with seven of those 13 participants showed cytotoxic ...

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Source: HighBeam Research, Lipopeptides Can Induce HIV Specific Immune Responses.(Brief Article)

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