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Combined Immunotherapy Regimen Shows Promise In Pilot Trial.(Brief Article)
2001 AUG 8 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A combined regimen of vaccination with CD40-activated malignant B cells and interleukin 2 (IL-2), along with autologous tumor-specific T-cell transfer, shows promise for therapy of B-cell malignancies and warrants further testing in a clinical trials, say researchers at the Dana Farber Cancer Institute, Boston.
"In a pilot study, we tested the feasibility and safety of combined immunotherapy consisting of adoptive transfer of autologous tumor-specific T-cells, low-dose IL-2, and a cellular vaccine of CD40-activated plasma cell leukemia (PCL) cells in a patient who failed tandem repeat stem cell transplantation and idiotype vaccination," reported J.L. Schultze and colleagues, who pointed out that most B-cell malignancies are currently incurable.
The researchers propagated autologous tumor-specific T-cells in vitro by repetitive stimulation with autologous ex vivo CD40-activated PCL cells and used coculture with CD40 ligand transfectants to generate CD40-activated PCL cells for vaccination. They infused autologous T-cells that were cytotoxic against autologous tumors into the patient, who tolerated them well.
The only adverse effects reported fever and myalgias closely related to IL-2 injections, noted Schultze and coworkers ("A pilot study of combined immunotherapy with autologous adoptive tumour-specific T-cell transfer, vaccination with CD40-activated malignant B cells and interleukin 2," British Journal of Haematology, 2001;113(2):455-460).
The first cycle of immunotherapy led to a temporary decrease of PCL cells in peripheral blood, the researchers found. Tumor ...
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Source: HighBeam Research, Combined Immunotherapy Regimen Shows Promise In Pilot Trial.(Brief...