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New York Findings Do Not Bear Out Intussusception Risk In Young Children.(Brief Article)
2001 AUG 8 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - The rate of intussusception among children younger than one year in New York was less than predicted during nine months of rotavirus vaccine use, epidemiologists there have found.
The findings of H.G. Chang and colleagues, New York State Department of Health, suggested that a causal relationship was small, if it existed at all.
The researchers examined hospital discharge data from 1989 through 1998 for children who were diagnosed with intussusception or rotavirus diarrhea and estimated the number of intussusception cases attributable to rotavirus vaccine based on vaccine penetration (21%) data from the National Immunization Program (NIP).
Over the course of the study period, 1,450 intussusception-associated hospitalizations were reported in children younger than one, for an average annual incidence of 5.4/10,000. The incidence decreased over time, from 6.1/10,000 in 1989 to 3.9/10,000 in 1998, Chang and coworkers found.
In a subset of 20 patients hospitalized during from October 1998 through June 1999 whose medical records and vaccine histories were analyzed, five had received rotavirus vaccine, all of whom were hospitalized after their first dose of vaccine and were admitted before they were seven months old.
Intussusception hospitalizations occurred throughout the year whereas rotavirus-associated hospitalizations peaked from February to April, they added.
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Source: HighBeam Research, New York Findings Do Not Bear Out Intussusception Risk In Young...