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Preschool DT Vaccine Should Be Replaced With aDTP.(Brief Article)
2001 AUG 8 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Countries currently immunizing pre-school children with boosters of diphtheria/tetanus (DT) vaccine should use an acellular diphtheria/tetanus/pertussis (aDTP) vaccines instead, recommend researchers working in England.
The aDTP booster confers greater protection from pertussis, which is apparently unimpaired by concurrent administration of measles, mumps, rubella (MMR) vaccine, reported E. Miller and associates at the Public Health Laboratory Service, London.
They compared aDTP vaccines to DT vaccines given as preschool boosters to 1,033 children ages four to less than six years who had completed primary immunization with DTP vaccine according to the U.K. two, three, and four month schedule; 71 children had received aDTP vaccine and the remaining 962 whole-cell DTP (wDTP) vaccine for the initial vaccine course. A subset of 374 children was evaluated for the effect of simultaneous MMR vaccine
Although DT and aDTP groups had similar frequencies of postvaccination symptoms, the aDTP group had local reactions sooner, reported Miller and coworkers. MMR vaccine had no effect on local reactions or fever within 10 days, they said, and children receiving it were no more likely than others to visit the doctor in the four- to six-week postvaccination period. The MMR vaccine had no significant effect on antibody responses to either the pertussis or diphtheria and tetanus antigens.
Pertussis antibody responses were consistent with the antigen content of the aDTP vaccines and were more protective against pertussis than a wDTP preschool booster given in an earlier trial, the researchers said.
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Source: HighBeam Research, Preschool DT Vaccine Should Be Replaced With aDTP.(Brief Article)