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Sibutramine Fails To Increase Energy Expenditure In African-American Women.(a drug for obesity)
2001 JUL 5 - (NewsRx Network) -- by N.R. Saltmarsh. staff medical writer - The obesity drug sibutramine apparently does not cause weight loss by boosting energy expenditure but rather by lowering energy consumption, according to a new report in Obesity Research.
Researchers proposed that the drug could be useful in African-American women, who have a high prevalence of obesity that may be partially explained by lowering rates of resting energy expenditure (REE).
R.D. Starling and associates at the University of Arkansas Medical Center recruited 15 premenopausal African-American women. whose body fat was 35% [+ or -] 7% for a double-blind cross-over study of energy expenditure at rest and after exercise.
Subjects ingested 30 mg of sibutramine or placebo, then submitted to REE tests 2.5 hours later. After that, they cycled at 70% aerobic capacity for 40 minutes, then were tested for energy expenditure for two hours. Each woman crossed over to the opposite study arm one month later.
Starling and coworkers found no difference between the sibutramine and placebo groups in terms of REE (23.70 [+ or -] 2.81 vs. 23.69 [+ or -] 2.95 kcal/30 min). exercise oxygen consumption (1.22 [+ or -] 0.15 vs. 1.25 [+ or -] 0.15 1/min), or post-cycling energy expenditure (104.2 [+ or -] 12.7 vs. 104.9 [+ or -] 11.4 kcal/ 120 min) ("Influence of sibutramine ...
- Sibutramine Fails To Increase Energy Expenditure In African-American Women.
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