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2001 JUL 5 - (NewsRx Network) -- A meta-analysis of eight recent observational studies suggests a reduction in hip and non-spine fractures among individuals taking statins, medicines commonly prescribed for the treatment of elevated cholesterol levels.
Douglas C. Bauer, MD, professor of medicine, epidemiology, and biostatistics at the University of California, San Francisco (UCSF) presented his research on "Statin Use and Fracture" at the first joint meeting of the International Bone and Mineral Society and the European Calcified Tissue Society in Madrid. Spain, on June 10, 2001.
"A meta-analysis of the studies support a protective effect of statins on hip and other types of fractures. although additional controlled trials of these agents among those at high risk of fracture are needed," Bauer said.
The analysis included eight observational studies in which some men and women used statins, or hepatic hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors. More than 200.000 subjects were studied, with statin users numbering more than 12,000 and the number of fractures totaling about 10,000. Hip fractures were reduced by nearly 60% among the individuals taking statins.
The analysis supported previous observations in animals that statins may ...