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DNA Immunization Of Mothers May Mean Better Response In Newborns.(genetic immunization)
2001 JUN 28- (NewsRx Network) -- by N.R. Saltmarsh, staff medical writer - Immunizing mother mice with naked DNA may ultimately lead to better vaccine efficacy in their offspring, say researchers working in the United States.
D.L. Radu and colleagues proposed that the influence of maternal antibodies could be preventing newborns and infants from receiving full efficacy from influenza vaccines and sought to overcome the problem by immunizing mothers with plasmid DNA.
"We investigated the effect of maternal antibodies on the anti-influenza virus protective response in progeny born to dams immunized with plasmid containing the hemagglutinin [HA] gene or UV-inactivated virus," reported Radu and coworkers.
The researchers immunized BALB/c dams with either virus or plasmid, then studied the effects of immunization on their offspring. They found that the inhibition period of anti-HA antibody response was shorter in mice born to DNA-immunized mice than those born to virus-immunized mice and that the persistent inhibitory effect on B cells continued even after the decline of maternal antibodies in offspring of mice immunized with virus or monoclonal antibodies.
When analyzing specific HA-specific clonotypes, Radu and associates found that "clonotypes producing antibodies specific for the ...
- Enterovirus 71 maternal antibodies in infants, Taiwan.(DISPATCHES)
- Magazine article from: Emerging Infectious Diseases Luo, Shu-Ting Chiang, Pai-Shan Chao, An-Shine Liou, Guan-Yuan Lin, Reyin Lin, Tzou-Yien Lee, Min-Shi April 1, 2009 700+ words
Transplacental maternal antibodies protect young infants from...diseases. On the other hand, maternal antibodies in young infants may impede...dynamics of pathogen-specific maternal antibodies in young infants (1-3...
- Maternal Antibodies.
- Newspaper article from: Vaccine Weekly January 25, 1999 700+ words
...Lambert, P.H. "Influence of Maternal Antibodies on Vaccine Responses: Inhibition...of Immunology, "The transfer of maternal antibodies to the offspring and their inhibitory...immunological bases. The influence of maternal antibodies on antibody and T-cell responses...
- Maternal Antibodies May Delay and Contain EBV In Infancy.(Brief Article)
- Newspaper article from: Virus Weekly June 5, 2001 700+ words
...medical writer - The persistence of maternal antibodies in the first months of life may...until the age of two. They found maternal antibodies in all cord blood samples and in...implicates a protective role for maternal antibodies," Chan and coworkers concluded...
- Maternal Antibodies May Delay and Contain EBV In Infancy.(Epstein-Barr virus)
- Newspaper article from: Immunotherapy Weekly Saltmarsh, N.R. June 6, 2001 700+ words
...medical writer - The persistence of maternal antibodies in the first months of life may...until the age of two. They found maternal antibodies in all cord blood samples and in...implicates a protective role for maternal antibodies," Chan and coworkers concluded...
- Oral swine fever vaccine in female wild boar elicited maternal antibodies.
- Newspaper article from: Science Letter December 21, 2004 700+ words
...to the development of maternal antibodies. "An experimental study...investigate the development of maternal antibodies after oral immunization...results demonstrated that maternal antibodies do not persist in the...
- Influence of Maternal Antibodies on Vaccine Responses: Inhibition of Antibody...
- Newspaper article from: Vaccine Weekly February 1, 1999 700+ words
...of Immunology, "The transfer of maternal antibodies to the offspring and their inhibitory...immunological bases. The influence of maternal antibodies on antibody and T-cell responses...elicited in presence of lower titers of maternal antibodies. However, even high titers of...
- Evaluation of a Hepatitis A Vaccine in Infants: Effect of Maternal Antibodies...
- Newspaper article from: Vaccine Weekly March 29, 1999 700+ words
...A Vaccine in Infants: Effect of Maternal Antibodies on the Antibody Response." J...Preliminary studies suggest that maternal antibodies interfere with the response of young...respectively. These results confirm that maternal antibodies interfere with the response to inactivated...
- Maternal antibodies contribute to a hematologic disorder in newborn infants.
- Newspaper article from: Health & Medicine Week December 29, 2003 700+ words
2003 DEC 29 - (NewsRx.com & NewsRx.net) -- Maternal antibodies contribute to a hematologic disorder in newborn infants. "From 1991 to 2000, amongst 23,886 full-term healthy Chinese babies...
