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Immunity After DTaP-HBV Vaccine Comparable With Natural Infection.(Brief Article)
2001 JUL 25 - (NewsRx.com & NewsRx.net) --
by Sonia Nichols, senior medical writer - Children who receive the combination vaccine against diphtheria, tetanus, pertussis, and hepatitis B (DTaP-HBV) develop protection against pertussis that closely resembles protection observed following natural infection.
Researchers in Italy at the University of Milan, the University of Palermo, and SmithKline Beecham compared immunity to pertussis in 38 children who received a triple-dose regimen of DTaP-HBV before the age of one year old with 21 children who developed pertussis infections by the same age. At the time of the study, the children were between the ages of five and six years old.
According to Susanna Esposito, University of Milan, and colleagues testing for immune response markers in the children's sera showed protection against pertussis was low in both groups, demonstrating the importance of vaccine booster doses for sufficient protection.
Although children who had received the vaccine showed slightly more of a type 2 immune response than children with natural immunity, overall differences between the numbers of immune response markers observed in each group was negligible ("Long-term pertussis-specific immunity after primary vaccination with a combined diphtheria, tetanus, tricomponent acellular ...
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