AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
V. Cholerae O139 Antigen Induces Immune Responses In Mice.(Brief Article)
2001 JUL 25 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - The 31-kDa antigen of Vibrio cholerae 0139 can induce protective humoral and cellular immune responses in mice and may one day have an application in preventing human cholera infection.
"In this study, the immune response to and protective role of a 31-kDa antigen of V. cholerae O139, reacting with IgA antibodies present in the sera of cholera patients and common to V. cholerae strains O139 and O1 was evaluated in BALB/c mice," reported S. Kumar and colleagues working in India.
They selected the 31-kDa antigen because it was common to both V. cholerae O139 and V. cholerae O1 and reacted to immunoglobulin A (IgA) antibodies in the sera from a cholera patient.
Kumar and coauthors purified the antigen using DEAE-Sepharose CL 6B column chromatography and administered it orally to BALB/c mice. The researchers observed an IgA response to the 31-kDA antigen in serum and intestinal fluid, and a proliferation of spleen lymphocytes upon stimulation with the same antigen.
Further analysis of these splenic lymphocytes revealed that a mixed Th1 and Th2 response of interferon-gamma and interleukin-10 was seen in the first week after infection and a Th2 response involving IL-10 predominated by the third week.
Hyperimmune serum to the 31-kDa antigen also was able to protect ...
- Synovial T cell proliferation to the Yersinia enterocolitica 19 kDa antigen...
- Magazine article from: Annals of the Rheumatic Diseases Appel, H Rudwaleit, M Wu, P Grolms, M Sieper, J Mertz, A June 1, 2002 700+ words
...tract such as Chlamydia trachomatis. (2) Identification of the structure of antigens of triggering microbes which drive immune responses in the synovial fluid would be of great interest. We recently described two major antigens, the Ye 19 kDa and the Ye...
- Predicted B-cell epitopes on 18 kDa antigen of Haemophilus ducreyi.(Letter To...
- Magazine article from: Indian Journal of Dermatology, Venereology and Leprology Wiwanitkit, Viroj November 1, 2008 700+ words
Byline: Viroj. Wiwanitkit Sir, Chancroid is an important sexually transmitted infection. This infection is caused by Haemophilus ducreyi .[sup] [1] This fastidious, gram-negative coccobacilli dies rapidly outside the human host, making diagnostic testing using culture methods difficult.[sup] [1]
- Breast cancer risk and immune responses in healthy women.(Clinical report)
- Magazine article from: Oncology Nursing Forum Park, Na-Jin Kang, Duck-Hee November 1, 2006 700+ words
...association with psychological distress and immune responses in healthy women with a family history...breast cancer have shown decreased immune responses (i.e., low natural killer cell...cancer risk is associated with impaired immune responses and exaggerated biophysiologic ...
- Enhancement of mucosal immune responses by chimeric influenza HA/SHIV...
- Magazine article from: Research Initiative/Treatment Action! Yao, Qizhi March 22, 2003 700+ words
...Abstract To enhance mucosal immune responses using simian-human immunodeficiency...both humoral and cellular immune responses at multiple mucosal sites...both humoral and cellular immune responses, and they can be administered...
- Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in...
- Magazine article from: Alternative Medicine Review Huang, Y.C. Chang, H.H. Huang, S.C. September 1, 2005 700+ words
...phosphate is a significant indicator of immune responses in the mechanically ventilated critically...the effect of vitamin B6 status on immune responses in mechanically ventilated, critically...sensitivity C-reactive protein, and immune responses (white blood cell, neutrophil...
- Immune responses to tumour antigens: implications for antigen specific...
- Magazine article from: Journal of Clinical Pathology Jager, D Jager, E Knuth, A September 1, 2001 700+ words
...the assessment of antigen specific immune responses have been defined--delayed type...antigens known to date, with spontaneous immune responses observed in 50% of patients with...to induce both humoral and cellular immune responses in vivo. (J Clin Pathol 2001;54...
- DNA vaccine elicits humoral and cellular immune responses in lymphoma patients.
- Newspaper article from: Immunotherapy Weekly January 8, 2003 700+ words
...four patients per dosage regimen). Immune responses specific to the MsIg segment of the...responses in four and cellular (T cell) immune responses in four. One patients also had an...measurable humoral and/or cellular immune responses. No adverse side effects or complications...
- Immune responses in patients with hepatitis C and HIV described.
- Newspaper article from: AIDS Weekly May 31, 2004 700+ words
...Scientists describe virus dynamics and immune responses during treatment in patients co...03), and baseline HCV-specific immune responses were significantly higher in the three...alpha; and both innate and adaptive immune responses may be important determinants of HCV...
- New data on Remune suggests HIV-1 specific immune responses.
- Newspaper article from: Pharma Business Week July 5, 2004 700+ words
...generated robust HIV-1 specific immune responses in a number of assaid. Ability to generate HIV-1 specific immune responses is thought to be an important...key markers of HIV-specific immune responses, including gamma interferon...
- The Immune Response Corporation Announces Study Suggesting Protection From HIV...
- Press release article from: PR Newswire October 17, 2002 700+ words
...Genital and Vaginal HIV-Specific Immune Responses Resulting From Innovative Intranasal...CpG ODN) induces HIV-specific immune responses in genital and vaginal tracts and...of inducing protection and potent immune responses in the genital tract against infection...
Source: HighBeam Research, V. Cholerae O139 Antigen Induces Immune Responses In Mice.(Brief...