AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Vaccination With MUC1 Peptide Is Effective Against Tumors In Vitro.(Brief Article)
2001 JUL 25 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Human polymorphic epithelial mucin (MUC1) shows efficacy against several MUC1-expressing tumor cell lines and may be ready for further refinement in clinical trials in breast cancer patients, according to a new report in the International Journal of Cancer.
MUC1 is a glycoprotein expressed on glandular epithelia and overexpressed and hypoglycosylated in adenocarcinomas, explained F.G.M. Snijdewint and colleagues in the Netherlands.
"The objective of our study was to determine whether humanized MUC1 monoclonal antibodies (MAbs) and antibodies (Abs) induced by vaccination of breast cancer patients with MUC1 peptides can effect an antibody-dependent cell-mediated cytotoxicity (ADCC)," said Snijdewint and coworkers.
The researches set up an in vitro assay using the breast tumor cell line ZR-75-I as the target and peripheral blood mononuclear cells (PBMC) of health donors as effectors, along with various MUC1 MAbs, to test efficacy.
They found that the humanized MAb HuHMFG-1 induced cell-mediated cytotoxicity in nine MUC1-expressing tumor cell lines - including three bone marrow-derived cell lines - as well as two MUC1-transfected cell lines, to different degrees.
The PBMC from healthy donors exhibited large variations in killing capacity, and NK cells were the essential effectors for the MUC1 Ab-dependent killing, reported Snijdewint and team. Furthermore, plasma samples obtained from breast cancer patients before and after ...
- Asterand to Distribute University of Michigan Breast Cancer (SUM) Cell Lines.
- Press release article from: PR Newswire February 8, 2005 700+ words
...distribution of eleven breast cancer cell lines, derived at the University...the marketing of the breast cancer cell lines, known as the SUM lines...diagnoses worldwide of breast cancer each year. The cell lines can be used to study...
- Precursor steroids have differential effects on breast cancer cell lines.
- Newspaper article from: Cancer Weekly June 8, 2004 700+ words
...differential effects on breast cancer cell lines. "Epidemiological studies...activities on the growth of breast cancer cell lines. In this study the proliferative...MCF7, T47D and MDAMB231 breast cancer cell lines have been examined by a...
- Inhibiton Therapeutics Provides Update for ICA-1 Compound in-Vitro Testing in...
- Press release article from: Business Wire January 16, 2008 700+ words
...testing in various cancer cell lines. The present work performed...the effects of ICA-1 on breast cancer cells have also obtained...proliferation of MDA-MB-468 breast cancer cells by 83% compared to...concentrations. For MCF-7 breast cancer cells, ICA-1 was effective...
- Onconase shows efficacy against NSCL and breast cancer cell lines.(non-small...
- Newspaper article from: Pharma Marketletter April 23, 2007 700+ words
...in preclinical models of non-small cell lung and breast cancer. The findings, which formed the basis of a poster...NCI-H1975, and MDA-MB-231 and MCF-7 human breast cancer cells, without damaging non-cancerous cells.
- Biotherapies Incorporated Scientists Develop Immortalized Cell Lines;...
- Press release article from: PR Newswire April 15, 2002 700+ words
...specializing in breast cancer therapies, announced...immortalized "normal" cell lines. These immortalized...to millions of breast cancer patients worldwide...The immortal cell lines continue to grow...treatment of breast cancer." Biotherapies...
- Research on breast cancer described by scientists at Mayo Clinic, Department of...
- Newspaper article from: Cancer Weekly June 16, 2009 700+ words
...normal breast, as well as breast cancer cell lines, were evaluated for protein...the invasive behaviour of breast cancer cell lines in two-dimensional...Invasive behaviour in breast cancer cell lines has been linked to matrix...
- Reports outline breast cancer study results from D.Q. Cai et al.
- Newspaper article from: Blood Weekly June 18, 2009 700+ words
...protein expression in human breast cancer cell lines. The purpose of our present...seven non-bone metastatic breast cancer cell lines were also determined using...in the bone metastatic breast cancer cell lines and tumor tissues compared...
- New breast cancer study results reported from L. Chen et al.
- Newspaper article from: Cancer Weekly September 1, 2009 700+ words
...primary tumors and cell lines from breast cancer. We also examined...29 of 30 (97%) breast cancer cell lines. Immunohistochemical...methylated in both cell lines and primary tumors from breast cancer, and the extent of...
Source: HighBeam Research, Vaccination With MUC1 Peptide Is Effective Against Tumors In...