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M. Vaccae Immunization Fails To Stop Asthma.(Brief Article)
2001 JUL 25 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Despite indications on several fronts that exposure to mycobacteria could prevent or treat asthma, a new study from New Zealand has found no such effect.
The findings of P.M. Shirtcliffe and colleagues at the Wellington School of Medicine did not add weight to studies published in the Chinese medical literature, which indicated that repeated bacillus Calmette-Guerin vaccine could successfully treat asthma.
The New Zealand researchers did not deny the heft of experimental and epidemiological evidence in support of the mycobacteria-asthma link, however.
The researchers randomized 43 patients with stable, moderately severe asthma to receive two intradermal injections of either placebo, heat-killed Mycobacterium vaccae (0.5 mg), or delipidated deglycolipidated M. vaccae (DDMV, 0.05 mg). They then measured markers of asthma severity for three months, along with immunoglobulin E (IgE) levels and T-cell proliferative and cytokine responses.
None of the markers was different among the groups nor were levels of eosinophils, IgE, or T-cell proliferative and cytokine responses, reported Shirtcliffe and coworkers ("The effect of delipidated ...
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Source: HighBeam Research, M. Vaccae Immunization Fails To Stop Asthma.(Brief Article)