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Revaccination Effective In Rare Cases of Hib Vaccine Failure.(Brief Article)
2001 JUL 25 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Although the conjugated Haemophilus influenzae type b (Hib) vaccine is highly effective against invasive Hib in children, vaccine failures occasionally have been reported.
M.A. Breukels and colleagues in the Netherlands reported 21 such cases since the introduction of the vaccine there and described follow-up findings in 14 of the patients.
Six showed no antibody response to Hib polysaccharide during their convalescence from Hib infection (immunoglobulin (Ig) anti-Hib
Revaccination restored anti-Hib antibodies in almost all the children, reported Breukels and coworkers, who recommended investigation of any case of Hib failure, including measurements of specific anti-Hib antibodies and serum IgG concentrations ("Immunological characterization of conjugated Haemophilus influenzae type b vaccine failure in infants," Clinical Infectious Diseases, June 2001;32(12):1700-1705).
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Source: HighBeam Research, Revaccination Effective In Rare Cases of Hib Vaccine Failure.(Brief...