AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Oral Vaccine Could Offer Palatable Alternative To Parenteral Delivery.(vaccine against human papillomavirus)
2001 JUN 21 - (NewsRx Network) -- by N.R. Saltmarsh, staff medical writer -- An oral vaccine against human papillomavirus (HPV), the causative agent of cervical cancer, has been brought one step closer to reality by researchers in the United States.
Parenteral delivery of HPV recombinant virus-like particles (VLPs) is already being studied in humans, but the oral equivalent would be a lower-cost and more attractive option, proposed S. Gerber and associates, University of Rochester Medical Center, New York.
"Vaccines formulated for injection generally are more costly, more difficult to administer, and less acceptable to recipients than are mucosally administered vaccines," they noted.
Oral vaccination with HPV type 11 had already shown modest success in mice, wrote Gerber and coauthors in the Journal of Virology, and their work evaluated the potential of VLPs of HPV-16 and HPV-18, which cause almost all cervical cancers.
Not only were these VLPs immunogenic when given orally, but their potency was also enhanced by coadministration with Escherichia coli heat-labile enterotoxin (LT) mutant R192G (LTR192G) and, to a lesser extent, CpG DNA.
Use of these adjuvants "can significantly improve anti-VLP humoral responses in peripheral blood and in genital mucosal secretions," ...
- Is human papillomavirus an infectious cause of non-cervical anogenital tract...
- Magazine article from: British Medical Journal Strickler, Howard D. Schiffman, Mark H. September 13, 1997 700+ words
...demonstrate in the study of human papillomavirus infection as a cause of...In cervical cancers human papillomavirus DNA can be detected in...Moreover, cervical human papillomavirus has been detected before...
- Cigarette smoking and human papillomavirus in patients with reported cervical...
- Magazine article from: British Medical Journal Burger, M.P.M. Hollema, H. Gouw, A.S.H. Pieters, W.J.L.M. Quint, W.G.V. March 20, 1993 700+ words
...smoking and infection with oncogenic human papillomavirus. It has been suggested that smoking...the infection and persistence of human papillomavirus. Design--Cross sectional epidemiological...analysis of cervical scrapes for human papillomavirus, and morphological examination...
- Predictive value of human papillomavirus type for histological diagnosis of...
- Magazine article from: British Medical Journal Burger, M.P.M. Hollema, H. Pieters, W.J.L.M. Quint, W.G.V. January 14, 1995 700+ words
...The broad spectrum of different human papillomavirus types has recently been grouped...tree lead to specific groups of human papillomavirus types with similar tissue tropism...viruses such as types 31 and 33. Human papillomavirus type 18 belongs to a separate main...
- CpG DNA induces refractoriness in RAW264.7 cells.
- Newspaper article from: Immunotherapy Weekly March 12, 2003 700+ words
...not been known whether previous exposure to CpG DNA induces a similar suppressive response to subsequent stimulation with CpG DNA. "In the present study, we demonstrate that pretreatment with CpG DNA induces suppression of cytokine release in...
- Human papillomavirus infection: pathogenesis suggests new strategies for...
- Magazine article from: British Medical Journal Hines, Jeffrey F. Ghim, Shin-Je Jenson, A. Bennett March 2, 1996 700+ words
...existing scientific evidence of human papillomavirus and its association with invasive...To date, more than 70 types of human papillomavirus have been described. Each type...between anogenital infection with human papillomavirus and the development of cervical...
- Anal human papillomavirus infection in heterosexuals with genital warts:...
- Magazine article from: British Medical Journal Sonnex, C. Scholefield, J.H. Kocjan, G. Kelly, G. Whatrup, C. Mindel, A. Northover, J.M.A. November 16, 1991 700+ words
...subclinical manifestations of anal human papillomavirus infection have been well reported...the prevalence of subclinical anal human papillomavirus infection in heterosexual people...previously. The mode of transmission of human papillomavirus to the anus is poorly understood...
- Human papillomavirus testing and the management of women with mildly abnormal...
- Magazine article from: British Medical Journal Rebello, Gemma Hallam, Nick Smart, George Farquharson, David McCafferty, Jane April 14, 2001 700+ words
...pilot scheme screening women for human papillomavirus if they have a mildly dyskaryotic...1] How reliable is testing for human papillomavirus as a marker for high grade disease...consented to the study were tested for human papillomavirus (high risk types only) with the...
- Cross sectional study of conventional cervical smear, monolayer cytology, and...
- Magazine article from: British Medical Journal Coste, Joel Cochand-Priollet, Beatrix de Cremoux, Patricia Le Gales, Catherine Cartier, Isabelle Molinie, Vincent Labbe, Sylvain Vacher-Lavenu, Marie-Cecile Vielh, Philippe April 5, 2003 700+ words
...tests, monolayer cytology, and human papillomavirus testing for screening for cervical...high incidence of abnormalities. Human papillomavirus testing associated with monolayer...cytology, possibly combined with human papillomavirus testing, is replacing conventional...
- Serologically diagnosed infection with human papillomavirus type 16 and risk...
- Magazine article from: British Medical Journal Lehtinen, Matti Dillner, Joakim Knekt, Paul Luostarinen, Tapio Aromaa, Arpo Kirnbauer, Reinhard Koskela, Pentti Paavonen, Jorma Peto, Richard Schiller, John T. Hakama, Matti March 2, 1996 700+ words
...Objective--To study human papillomavirus type 16 in the aetiology...of past infection with human papillomavirus type 16. Subjects...of IgG antibodies to human papillomavirus type 16. Results...
- Prospective seroepidemiological study of role of human papillomavirus in...
- Magazine article from: British Medical Journal Bjorge, Tone Dillner, Joakim Anttila, Tarja Engeland, Anders Hakulinen, Timo Jellum, Egil Lehtinen, Matti Luostarinen, Tapio Paavonen, Jorma Pukkala, Eero Sapp, Martin Schiller, John Youngman, Linda Thoresen, Steinar September 13, 1997 700+ words
...epidemiological data have implicated human papillomavirus as a cause of cervical cancer.[1 2] Human papillomavirus DNA has been detected in more than 90% of invasive cancers.[3] Human papillomavirus type 16 is the dominant subtype...
Source: HighBeam Research, Oral Vaccine Could Offer Palatable Alternative To Parenteral...