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Stem Cell Cleansing Can Reduce Complications.(of chemotherapy for breast cancer)
2001 JUN 21 - (NewsRx Network) -- by Michael Greer, senior medical writer - A procedure for removing harmful substances from stem cell grafts can reduce the risk of chemotherapy complications for breast cancer patients, oncologists in Italy report.
"The majority of high-dose chemotherapy (HDC)-related complications results from bone marrow aplasia," explained L. Del Mastro and colleagues at Genoa's National Institute for Cancer Research. "[B]ut the graft infusion per se may cause adverse reactions due to the injection of both dimethyl sulfoxide (DMSO) and cell lysis products."
The novel cleaning process studied by Del Mastro and coworkers successfully removed these toxic substances from cryopreserved stem cell autografts, they said.
Of the 20 patients recruited for this study, 18 successfully completed three cycles of normal CEF (cyclophosphamide, epirubicin, and 5-fluorouradil) chemotherapy, followed by three high-dose cycles of cyclophosphamide and carboplatin with peripheral blood progenitor cell (PBPC) support. None of the 20 participants suffered from PBPC-specific adverse effects after DMSO and cell lysis products were removed from the grafts, the researchers reported.
The maximum tolerated dose (MTD) of cyclophosphamide with this regimen was 3000 mg/[m.sup.2], study data showed, with a carboplatin MTD of 600 ...
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Source: HighBeam Research, Stem Cell Cleansing Can Reduce Complications.(of chemotherapy for...