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HIV Positive Women At High Risk For Pre-Cancerous Lesions.
2001 JUN 21 - (NewsRx Network) -- HIV positive women are three times more likely than other women to develop lesions that can lead to anal cancer, new research shows.
The greater risk is due at least in part to weakened immune defenses against the common sexually transmitted human papillomavirus (HPV).
The research findings by scientists at the University of California, San Francisco, are published in the June 6, 2001, issue of the Journal of the National Cancer Institute.
"HPV already has been shown to increase risk of developing cervical cancer, but our research shows HPV also increases abnormal development of anal cells that may lead to anal cancer in women," said Elizabeth Holly, PhD, MPH, lead author of the study and UCSF professor of epidemiology and bio statistics.
Senior author on the study is Joel Palefsky, MD, UCSF professor of laboratory medicine and stomatology, who, along with the other authors on this paper, has made similar findings regarding HIV positive men.
The researchers conclude that HIV positive women may benefit from anal exams and assessments of anal cells, although further research is needed. Those with abnormal lesions should be carefully followed up, they say.
In the study, higher rates of anal cancer precursor cells were found in HIV positive women with anal HPV infection, lower CD4 cell counts (a common indicator of a weakened immune system), a history of anal intercourse, and abnormal cervical cells. "We found a number of risk factors associated with increased anal cancer risk among HIV positive women," Holly said. "But the strongest is the presence of HPV."
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