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Genetic Influences Determine Some Responses To TB Antigens.(Brief Article)

Vaccine Weekly

| July 11, 2001 | COPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 JUL 11 - (NewsRx.com & NewsRx.net) --

by N.R. Saltmarsh, staff medical writer - A study of twins in West Africa has clarified the role of genetics in immune response to Mycobacterium tuberculosis antigens.

A. Jepson and colleagues working in England pointed out that although the research community is starting to recognize genetic influences on clinical TB infection, less is known about how genetics affect immune responses in healthy people.

Their study of 255 adult twin pairs in Gambia revealed that genetic factors determine memory T-cell responses to 85-kDa antigen complex, "short-term culture filtrate," peptides from the ESAT-6 protein, and the 65-kDa heat shock protein, as well as to intradermal tuberculin.

Environmental factors, on the other hand, are responsible for quantitative T-cell and antibody responses to the 38-kDa cell membrane protein, reported Jepson and team ("Genetic regulation of acquired immune responses to ...

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Source: HighBeam Research, Genetic Influences Determine Some Responses To TB Antigens.(Brief...

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